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Methotrexate has been used as a steroid sparing agent in subarachnoid disease in patients requiring long-term steroids and experiencing intolerable side effects 99 .

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The good newsThese side effects can often be short-circuited by taking a folic acid supplementFolic acid is the synthetic form of folateOne study found that RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent.

Live vaccinesWhen used with methotrexatelive vaccines raise your risk of infectionThe vaccine may also not work as wellLive vaccinessuch as FluMistare vaccines that contain small amounts of livebut weakenedviruses

For psoriasismethotrexate slows down permethrin 5 percent. how fast your body produces the top layer of your skinThis helps to treat the symptoms of psoriasiswhich include dryitchy patches of skin.

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methotrexate usually at high dosages has rarely caused severe sometimes fatal blood bone marrow problems decreasing your body s ability to fight infections and stomach intestinal disease such as bleeding when used at the same time as non-steroidal anti-inflammatory drugs nsaids such as indomethacin, ketoprofen .

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